Drug Baron

October 29, 2012
by admin

Bardoxolone and BG-12: A Tale of Two CITIEs (Covalently-Interacting Therapeutic IntErventions!)

Until 18th October, bardoxolone methyl (Abbott/Reata) and BG-12 (Biogen) had two things in common: the nrf2 transcription factor complex as their molecular target; and their candidacy for blockbuster status. Then Reata halted clinical development of bardoxolone, following an excess of … Continue reading